System Updates - OnCore/eReg

Occasional OnCore and eReg system updates are necessary to ensure optimum system functionality and maintain high standards of security for clinical trial data. To minimize disruption to OnCore and eReg users, updates will occur outside of normal business hours (overnight or on weekends). Additionally, OnCore Support provides the maintenance schedule outlined here so that clinical trial teams can plan their work accordingly.


Application server operating system updates are applied using automation. During these periods once a month, there will be a single, brief restart of the application server running your product(s) for 5 minutes between the hours of 12am and 4am Central Time each month on the following schedule:

Non-Production Apps Production Apps
1st Saturday of each month 3rd Saturday of each month


Maintenance tasks on database servers include applying the latest database security updates, operating system updates and general maintenance tasks. Maintenance windows for database servers will run on a quarterly basis on the following dates from 6:00am to 4:00pm Central Time and will impact all applications noted below. Actual end time is estimated and may vary based upon the tasks required during specific periods. 

Non-Production Databases

Production Databases
November 5, 2022 November 19, 2022

Please note that non-Production and Production maintenance is separated by a two-week period. The above schedules will be in effect for all Advarra Managed Infrastructure products listed below:

OnCore® Enterprise Research
Advarra eRegulatory Management System™ (eReg)
Advarra EDC™
Advarra Research Evaluation System™ (EVAL)
Advarra Hub
Advarra Insights
Advarra Payments