System Updates - OnCore/eReg

Occasional OnCore and eReg system updates are necessary to ensure optimum system functionality and maintain high standards of security for clinical trial data. To minimize disruption to OnCore and eReg users, updates will occur outside of normal business hours (overnight or on weekends). Additionally, OnCore Support provides the maintenance schedule outlined here so that clinical trial teams can plan their work accordingly.


Application server operating system updates are applied using automation. During these periods once a month, there will be a single, brief restart of the application server running your product(s) for 5 minutes between the hours of 12am and 4am Central Time each month on the following schedule:

Non-Production Apps Production Apps
1st Saturday of each month 3rd Saturday of each month


Maintenance tasks include applying the latest database security updates, operating system updates, and general maintenance tasks. Maintenance windows for database servers will run on the following dates from 6:00 AM to 4:00 PM Central Time. Non-Production and Production maintenance is separated by a two-week period of time.

Non-Production Databases

Production Databases
May 6, 2023 May 20, 2023
August 5, 2023 August 19, 2023
September 9, 2023 September 23, 2023
November 4, 2023 November 18, 2023

The above schedules will be in effect for all Advarra Managed Infrastructure products listed below:

OnCore® Enterprise Research
Advarra EDC™
Advarra Research Evaluation System™ (EVAL)
Advarra Hub
Advarra Insights
Advarra Payments

Please note that as of Saturday January 28, 2023 the following application will be deployed on Advarra Cloud and will not be impacted by Advarra Managed Infrastructure planned maintenance windows:

Advarra eRegulatory Management System™ (eReg)